Currently, the latest league of The Last of the Druids in Path of Exile 2 is in its mid-stage, and many players have completed the main campaign and entered the endgame through the interlude. In this more challenging game content, you will no longer face low- to mid-level monsters, but bosses with extremely high health and damage output.
In particular, Anomaly bosses added in the last league, and their encounters, although difficult to complete, are very valuable because you can find exclusive Lineage Support Gems from their drops, which can make your character’s endgame builds more effective. 
After the changes in patch 0.4.0, there are 4 Anomaly bosses existing in POE 2, who previously appeared in Act 4 and three interludes. Since these encounters are all in the endgame, they are much more difficult to complete than those in the main campaign. So, you might really need this guide to killing Anomaly bosses from EZG.com.
1. Manoki, The Chosen
The first character introduced here is Manoki, the Chosen, whose prototype is Karui Chieftain, Tavakai from Act 4. It appears in Jade Isle map, but the way to enter the map is a bit peculiar: because its outer perimeter is shrouded in a vortex, you need to remove it before you can enter.
To clear the whirlpool, you need to explore Atlas near the water until you see a white whirlpool. Don’t interact with it yet; you need to clear the map connected to it and deactivate a Karui Beacon. This will unlock Jade Isle map.
Following the route explored on this map, you will soon find Manoki, the Chosen, the boss who has been waiting for you. Your encounter with it is still divided into three phases. Below are the key points and combat strategies for each phase.
Phase 1
In this phase, you will fight Manoki in semi-human form. Once its health drops to around 60%, the boss will transform and flee towards Tukohama’s shrine. Be sure to catch up with it and attack it during this time, otherwise it will regain full health. At the same time, be aware of its heavy blows.
Phase 2
Manoki will then launch attacks that have a corrupted effect, as well as some powerful heavy blows, which you need to dodge in time. Many attacks will cause the ground to grow spikes, but there is no need to worry too much, as their generation time is somewhat delayed. When its health drops to around 80%, the boss will transform again and regain full health.
Phase 3
At this point, the boss’s movement and attack speed will increase significantly, and it will also unleash numerous area-of-effect attacks. Therefore, you cannot prolong this phase of the battle, otherwise the entire arena will be covered by its area-of-effect damage, which will consume a lot of your healing potions and pose a significant threat.
However, this is merely a delaying tactic. To completely avoid immediate death after being attacked, you need to buy PoE 2 currency from EZG.com, where can enjoy a 10% OFF here using "XMAS" Code, allowing the equipped items to provide you with the maximum healing power.
After you have gone through all the hardships to complete this encounter, you will receive the following rewards:
- Kaom’s Madness
- Rakiata’s Flow
- Tawhoa’s Tending
- Tasalio’s Rhythm
2. Varloch, The Ashen Lord & Avelyne, The Withered Rose
This boss combination is located in Derelict Mansion map in Atlas of POE 2 The Last of the Druids league. This map and the encounter are sampled from The Curse of Holten Interlude. To enter it, you need to activate Draioch Hengestones in the connected maps first, which is very simple and can be done in two minutes.
Although bats fly around the map, they pose no threat to you, so you can safely search every house on the map to farm POE 2 currency and experience points by killing some low-level monsters. At the end of the map exploration, you will encounter Varloch, the Ashen Lord, and Avelyne, the Withered Rose.
Varloch’s attack style is very similar to Draven’s in Act 1, but more lethal; and Avelyne is a variant of Asinia, both possessing similar attack moves and the same weaknesses. Therefore, you only need to pay attention to the following two points.
Varloch will slam his sword into the ground, which is easy to dodge. However, you should pay more attention to the shockwaves that follow the slam and spread to the sides, which will cause you to lose a lot of health. Remember to use potions to replenish your lost health points promptly.
Avelyne will occasionally trap you in a Bone Cage and summon an Orbital Strike in that area, a brief but continuous damaging attack. You need to break Bone Cage quickly and escape. Defeating these two bosses will you receive the following rewards:
- Rigwald’s Ferocity
- Ailith’s Chimes
- Einhar’s Beastrite
3. Zahmir, The Blade Sovereign
Your encounter with Zahmir will take place on Sacred Reservoir map. You’ll need to remove Temporal Sandstorm in the desert to find it, which requires you to disable the three Temportal Tethers located in the connected maps.
This boss is a bit different from the previous ones; although its prototype is Azmadi, the Faridun Prince from The Stolen Barya Interlude, the challenge is somewhat reduced, making it less difficult. That being said, this battle still consists of two phases, as follows:
Phase 1
Although Zahmir will launch some combos at you, these attacks are predictable, so you can easily dodge them. It’s worth noting that these attacks not only damage you but also inflict a stagger effect, stunning you, so be extremely careful. When its health drops to around 40%, Zarokh, the Temporal, will pause time and restore the boss’s health to full.
Phase 2
Although he has entered the second phase, Zahmir’s attack power has not increased substantially. He will only unleash multiple time-related attacks, each with a slight delay. You can use this delay to observe the attack trajectory and dodge, but some attacks will miss the target, so be extra careful.
After completing all the dodging and killing maneuvers, you will receive the following rewards:
- Varashta’s Blessing
- Khatal’s Rejuvenation
- Zarokh’s Refrain
- Garukhan’s Resolve
4. Ytzara, Blood Oracle & Maztli, Flesh-Shaper
This last group of Anomaly bosses are Vaal brother-sister duo from Interlude 3 of Path of Exile 2. You can find them in the mountains area of Estazunti’s Vault map; they are surrounded by a ring of corruption oozing, making them easy to spot. With the changes in the latest patch 0.4.0, you no longer need to search for Idol of Estazunti in connected maps to unlock this map.
Nowadays, once you defeat the bosses in these maps, a floating pillar will appear, allowing you to enter Estazunti’s Vault map. The only thing to be careful about in this encounter is not to focus on damaging or killing one of the bosses, because if one dies, the other will receive an unprecedented boost. Here are some things you need to pay attention to:
The primary concern is Claw attack from the female boss, which drains some of your health to heal herself. So, try to avoid this type of attack as much as possible and increase your own defense. And Corrupted Beam cast by the male boss will also deal you significant damage.
Additionally, you need to be aware that the male boss will transform into Vaal Goliath during the battle, granting him an additional area-of-effect attack. To counter this attack, you must stay as far away from the area of effect as possible.
After successfully defeating these two bosses, you will receive the following rewards:
- Atalui’s Bloodletting
- Tacati’s Ire
- Paquate’s Pact
The above are the methods and precautions for finding and defeating all Anomaly bosses in the latest League of Path of Exile 2. Hopefully, this guide will help you complete all the encounters faster and claim the very generous rewards. Enjoy the game under the influence of patch 0.4.0!